Gut T2D, IR, NAFLD, CVD

By pjain      Published Oct. 17, 2020, 9:55 p.m. in blog Health   

Gut Metabolism and IR

Gut and NAFLD

Diet interventions for Gut health and preventing NAFLD

Gut and NAFLD mechanisms, Pathways

A low-nutrient carbohydrate-rich but protein/fat-deficient, diet reflects dietary shifts in poorer undernourished communities

NAFLD studies

  • dn NAFLD Fatty Liver and Altered Gut Microbiota during Early-Life Undernutrition mSystems-2020-Bauer-e00499-20.full

Gut and T2D

Gut and T2D

Carbs, low fiber -> promote IR biota

Higher levels of toxin-producing bacteria, such as enterobacteria, in the gut can lead to insulin resistance, which means people would not feel full, bodies were not telling them they are satisfied after eating one bowl of rice, instead needing five, 10 or 20 bowls to feel full. -- Prof Liping Zhao, at Shanghai Jiao Tong University

  • Changing the bacteria could switch on a gene which makes the body burn fat.

Gut Biomes and Type 2 Diabetes 101

TRs Summary

The incidence of type 2 diabetes is known to correlate with both genetic and environmental factors, and it has been suggested that alterations in the intestinal microbiota may also be involved.

Biomarkers from Fecal profiling of T2D - Metagenome-wide association study (MWAS)

MWAS compares the combined genetic content of the faecal microbiota between healthy people and those with diabetes. They identify multiple microbial species and metabolic pathways that are associated with either cohort and show that some of these may be used as biomarkers

  • 2012 Qin, J. et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55–60. Jun Wang BGI-Shenzhen, Shenzhen 518083, China

Improve Glucose Tolerance by predigesting sugars to SCFA

Improving glucose tolerance via energy metabolism pathways (colonic fermentation and generation of short-chain fatty acids);

Reducing inflammation

Altering the immune response - avoiding T1

Gut and CVD

BP references

* Priority to see
  • 2014 Pluznick, J. A novel SCFA receptor, the microbiota, and blood pressure regulation. Gut Microbes 5, 202–207
  • 2013 Pluznick, JL Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and BP regulation. Proc. Natl Acad. Sci. USA 110, 4410–4415

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