Diabetes, Metabolic, IR, TRs, Scr
Diabetes Scr, TRs
IR, Metabolic Syndrome Scr, TRs
Inflammation, Endotoxemia can cause IR, Obesity, NAFLD
Metabolic Endotoxemia > Inflammation > Obesity > IR
- Normal Endotoxemia increased in FED stated, reduced in FASTING state!
- bacterial lipopolysaccharide (LPS) are Bacterial lipopolysaccharides (LPS) are the major outer surface membrane components present in almost all Gram-negative bacteria and act as extremely strong stimulators of innate or natural immunity
Consequently they serve as a triggering factor for Inflammation
A high fat diet increased LPS containing microbiota in the gut. Presumably LEAKY GUT allows them to make into BLOOD STREAM plasma!
- After a duration of a 4-week high-fat diet chronically increased plasma LPS concentration (similar effect was by 4 weeks of continuous subcutaneous infusion of LPS.
- When LPS concentration increased two to three times, a threshold defined as metabolic endotoxemia this causes IR, Obesity = ie fasted glycemia and insulinemia and whole-body, liver, and adipose tissue weight gain were increased MICE: 2007 Cani Metabolic Endotoxemia Initiates Obesity and Insulin Resistance Diabetes 56:1761–1772. !dn