Diabetes, Metabolic, IR, TRs, Scr

By pjain      Published July 10, 2019, 6:51 p.m. in blog Health   

Diabetes Scr, TRs

IR, Metabolic Syndrome Scr, TRs

Inflammation, Endotoxemia can cause IR, Obesity, NAFLD

Metabolic Endotoxemia > Inflammation > Obesity > IR

  • Normal Endotoxemia increased in FED stated, reduced in FASTING state!
  • bacterial lipopolysaccharide (LPS) are Bacterial lipopolysaccharides (LPS) are the major outer surface membrane components present in almost all Gram-negative bacteria and act as extremely strong stimulators of innate or natural immunity
  • Consequently they serve as a triggering factor for Inflammation

  • A high fat diet increased LPS containing microbiota in the gut. Presumably LEAKY GUT allows them to make into BLOOD STREAM plasma!

  • After a duration of a 4-week high-fat diet chronically increased plasma LPS concentration (similar effect was by 4 weeks of continuous subcutaneous infusion of LPS.
  • When LPS concentration increased two to three times, a threshold defined as metabolic endotoxemia this causes IR, Obesity = ie fasted glycemia and insulinemia and whole-body, liver, and adipose tissue weight gain were increased MICE: 2007 Cani Metabolic Endotoxemia Initiates Obesity and Insulin Resistance Diabetes 56:1761–1772. !dn

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