Statins in Depth

By pjain      Published Oct. 27, 2019, 3:31 a.m. in blog Health   

Statins Takeaways

Statins Overview

Add CoQ10 supplements

Don't statin drugs cause heart failure in many people? You have recommended that I take a cholesterol-lowering statin drug (e.g. Lipitor, Mevacor, Zocor, Crestor, etc.). Its my understanding that these drugs deplete an important substance called Coenzyme Q10, and that this coenzyme is required for energy in the mitochondria of cells. If there is no coQ10, cells die. I know that a group of medical doctors blame these statin drugs for the recent increase in heart failures. Merck has several patents (1990) on how to overcome the CoQ10 depletion issue by adding CoQ10 to the statin drugs, but these Merck patents have never been implemented. Canada requires warnings about the CoQ10-depletion effect in their drug ads, and I know that the FDA is being sued to require these warnings in American drug ads.

Ninety days before Merck's first statin drug was marketed, there was wide publicity to the public and medical profession that niacin caused liver damage. They [ONLY] had 6 test subjects at the VA Hospital in St. Louis in the study. Nothing was said about the health of the test subjects liver function. This one study was the basis of discrediting niacin. he Statin manufacturers have not taken the ethical and medical steps to make sure no harm is done when the statin drug is prescribed. In 1991, Merck patented their formula of statin drugs and Co Q 10, but never brought to market. Their scientists in the 1980's recognized that Merck's statin drugs suppressed and depleted Co Q 10. What happened to the oath "Do no harm" ?

Don't statin drugs cause heart failure in many people? You have recommended that I take a cholesterol-lowering statin drug (e.g. Lipitor, Mevacor, Zocor, Crestor, etc.). Its my understanding that these drugs deplete an important substance called Coenzyme Q10, and that this coenzyme is required for energy in the mitochondria of cells. If there is no coQ10, cells die. I know that a group of medical doctors blame these statin drugs for the recent increase in heart failures. Merck has several patents (1990) on how to overcome the CoQ10 depletion issue by adding CoQ10 to the statin drugs, but these Merck patents have never been implemented. Canada requires warnings about the CoQ10-depletion effect in their drug ads, and I know that the FDA is being sued to require these warnings in American drug ads.

Add Vitamin D - Do Statins Lower it Further?

Statin BPR

SRC:http://articles.mercola.com/sites/articles/archive/2010/07/20/the-truth-about-statin-drugs-revealed.aspx

Statins cut Exercise Value

Statins Can Cut the Benefits of Exercise Kristian Sekulic / Getty Images

By GRETCHEN REYNOLDS May 22, 2013

An important new study suggests that statins, the cholesterol-lowering medications that are the most prescribed drugs in the world, may block some of the fitness benefits of exercise, one of the surest ways to improve health.

No one is saying that people with high cholesterol or a family history of heart disease should avoid statins, which studies show can be lifesaving. But the discovery could create something of dilemma for doctors and patients, since the people who should benefit the most from exercise — those who are sedentary, overweight, at risk of heart disease or middle-aged — are also the people most likely to be put on statins, possibly undoing some of the good of their workouts.

For the new study, which was published online in The Journal of the American College of Cardiology, researchers from the University of Missouri and other institutions gathered a group of overweight, sedentary men and women, all of whom had multiple symptoms of metabolic problems, including wide waistlines, high blood pressure or excess abdominal fat.

Most had slightly but not dangerously elevated cholesterol levels.

None had exercised regularly in the past year.

All underwent muscle biopsies and treadmill testing to determine their aerobic fitness — which was generally quite low — and agreed to continue with their normal diet.

Then they all began a supervised 12-week exercise program, during which they visited the university lab five times a week and walked or jogged on a treadmill for 45 minutes at a moderately vigorous pace (about 65 to 70 percent of their individual aerobic maximum).

Half of the group also began taking a daily 40-milligram dose of simvastatin, a particular type of statin sold under the brand name Zocor.

At the end of 12 weeks, the participants fitness and muscles were retested.

Statins, as most of us know, are medications designed to reduce the body’s cholesterol levels, particularly levels of low-density lipoprotein, or “bad” cholesterol. The drugs routinely are prescribed for those with high cholesterol and other risk factors for heart disease, and some physicians believe that they should be used prophylactically by virtually everyone over 50.

Exercise also typically is recommended as a means of fighting heart disease and prolonging life span.

And both statins and sweating indisputably are effective. In past studies, researchers have shown that statins reduce the risk of a heart attack in people at high risk by 10 to 20 percent for every 1-millimole-per-liter reduction in blood cholesterol levels (millimoles measure the actual number of cholesterol molecules in the bloodstream), equivalent to about a 40-point drop in LDL levels. Meanwhile, improving aerobic fitness by even a small percentage through exercise likewise has been found to lessen someone’s likelihood of dying prematurely by as much as 50 percent.

So, theoretically, it would seem that combining statins and exercise should provide the greatest possible health benefit.

But until the current study, no experiment scrupulously had explored the interactions of statin drugs and workouts in people. And the results, as it turns out, are worrisome.

The unmedicated volunteers improved their aerobic fitness significantly after three months of exercise, by more than 10 percent on average. But the volunteers taking the statins gained barely 1 percent on average in their fitness, and some possessed less aerobic capacity at the end of the study than at its start.

Why there should be such a discrepancy between the two groups’ fitness levels wasn’t clear on the surface. But when the researchers looked microscopically at biopsied muscle tissue, they found notable differences in the levels of an enzyme related to the health of mitochondria, the tiny energy-producing parts of a cell. Mitochondria generally increase in number and potency when someone exercises.

But in the volunteers taking statins, enzyme levels related to mitochondrial health fell by about 4.5 percent over the course of the experiment. The same levels increased by 13 percent in the group not taking the drug.

In effect, the volunteers taking statins “were not getting the same bang from their exercise buck” as the other exercisers, says John P. Thyfault, a professor of nutrition and exercise physiology at the University of Missouri and senior author of the study.

This finding joins a small but accumulating body of other studies indicating that statins can negatively affect exercise response. Lab rodents given statins, for instance, can’t run as far as unmedicated animals, while in humans, marathon runners on statins develop more markers of muscle damage after a race than runners not using the drugs.

None of which suggests, Dr. Thyfault says, that statins are not worthwhile. For people who have a family history of high cholesterol or heart disease or who themselves have high cholesterol, he says, “there’s no doubt that statins save lives.”

But for other people, the risk-benefit calculation involving statins may be trickier in light of this and other new science.

“Low aerobic fitness is one of the best predictors” of premature death, Dr. Thyfault says. And if statins prevent people from raising their fitness through exercise, then “that is a concern.”

A possible remedy, he continues, could be for people to get in shape and raise their aerobic fitness before starting the drug, but that’s an issue to discuss with your doctor. “There’s still a great deal we don’t understand” about how statins and exercise mix, he says.

Statins CoQ10 Controversy

the statins are killing people cus it takes the CoQ10 out of the? body and people have heart attacks!! If anyone on here takes statins, first you need to know that the UNDER 200 for cholesterol is dangerous and the statins rob your body of the coq10 that your heart needs to function, so take the coq10 if you continue to take statins. Why don't the stupid doctors subscribe CoQ10 when prescribing statins. This shows that doctors don't know or care that stations suppress glut4 and CoQ10.I looked at a CoQ10 bottle at Walgreens, guess what it says on the front of? the bottle. Statin users see warning on back. Statins users should be taking CoQ10 with the statins. No wonder so many people die on to many meds. Low cholesterol causes low ATP and cells die! Sore muscles are a symptom.

My new doc said that? metformin raises insulin. Why do you want more insulin when your cells don't take it in? Makes NO SENSE at all!! Having too much insulin makes you sicker, so why do i want more?And it will wear out your pancreas faster too, among other things, like going blind!! I have to do all of my own research to figure crap out and my head is spinning! It may be that gluten is causing leaky gut and causing all of our systems to go crazy. thyroid too

If You Take Statins, You MUST Take CoQ10

CoQ10 Core thesis

Statins deplete your body of CoQ10, which can have devastating results. If you take statin drugs without taking CoQ10, your health is at serious risk. Unfortunately, this describes the majority of people who take them in the United States. CoQ10 is a cofactor (co-enzyme) that is essential for the creation of ATP molecules, which you need for cellular energy production. Organs such as your heart have higher energy requirements, and therefore require more CoQ10 to function properly. Produced mainly in your liver, it also plays a role in maintaining blood glucose.

Physicians rarely inform people of this risk and only occasionally advise them to take a CoQ10 supplement. As your body gets more and more depleted of CoQ10, you may suffer from fatigue, muscle weakness and soreness, and eventually heart failure.

Coenzyme Q10 is also very important in the process of neutralizing free radicals. So when your CoQ10 is depleted, you enter a vicious cycle of increased free radicals, loss of cellular energy, and damaged mitochondrial DNA. If you decide to take a CoQ10 supplement and are over the age of 40, it is important to choose the reduced version, called ubiquinol. Ubiquinol is a FAR more effective form—I personally take it daily for its many far-ranging benefits. As for dosage, Dr. Graveline, a family doctor and former astronaut, made the following recommendation in a previous interview on statins and CoQ10:

    If you have symptoms of statin damage such as muscle pain, take anywhere from 200 to 500 mg
    If you just want to use it preventively, 200 mg or less should be sufficient

Optimizing Your Cholesterol Levels, Naturally

There's really no reason to take statins and suffer the damaging health effects from these dangerous drugs. The fact is that 75 percent of your cholesterol is produced by your liver, which is influenced by your insulin levels. Therefore, if you optimize your insulin levels, you will automatically optimize your cholesterol. It follows, then, that my primary recommendations for safely regulating your cholesterol have to do with modifying your diet and lifestyle:

    Optimize your vitamin D levels. Research by Dr. Stephanie Seneff has shed additional light on the extreme importance of appropriate sun exposure for normalizing your cholesterol levels and preventing heart disease. For more information, please see this previous interview.
    Reduce, with the plan of eliminating, grains and sugars in your diet. Ideally, you'll also want to consume a good portion of your food raw.
    Make sure you are getting plenty of high-quality, animal-based omega-3 fats, such as krill oil.
    Other heart-healthy foods include olive oil, coconut and coconut oil, organic raw dairy products and eggs, avocados, raw nuts and seeds, and organic grass-fed meats as appropriate for your nutritional type.
    Exercise daily. Make sure you incorporate Peak Fitness exercises, which also optimizes your human growth hormone (HGH) production.
    Address your emotional challenges. My favorite technique for stress management is the Emotional Freedom Technique (EFT).
    Avoid smoking or drinking alcohol excessively.
    Be sure to get plenty of good, restorative sleep.

Unlike statin drugs, which lower your cholesterol at the expense of your health, these lifestyle strategies represent a holistic approach that will benefit your overall health—which includes a healthy cardiovascular system.

Review of Statin Drugs

Basics

Statins are HMG-CoA reductase inhibitors, that is, they act by blocking the enzyme in your liver that is responsible for making cholesterol (HMG-CoA reductase).

The fact that statin drugs cause side effects is well established—there are now 900 studies proving their adverse effects, which run the gamut from muscle problems to increased cancer risk. For starters, reported side effects include: Muscle problems, polyneuropathy (nerve damage in the hands and feet), and rhabdomyolysis (a serious degenerative muscle tissue condition)

Statins Impair Numerous Biological Functions

Statin drugs also interfere with other biological functions, including an early step in the mevalonate pathway, which is the central pathway for the steroid management in your body. Products of this pathway that are negatively affected by statins include:

    All your sex hormones
    Cortisone
    The dolichols, which are involved in keeping the membranes inside your cells healthy
    All sterols, including cholesterol and vitamin D (which is similar to cholesterol and is produced from cholesterol in your skin)

It's still uncertain whether statins actually deplete your body of vitamin D, but they do reduce your body's natural ability to create active vitamin D (1,25-dihydroxycholecalciferol). This is the natural outcome of the drug's cholesterol-reducing ability, because you need cholesterol to make vitamin D! It's the raw material your body uses for vitamin D conversion after you've exposed your skin to sunlight. It's also well-documented that vitamin D improves insulin resistance, so needless to say, when you take a statin drug, you forfeit this 'built-in' health-promoting mechanism, which is yet another clue as to how statins can cause diabetes.

Primary Prevention - Unwarranted!

Secondary - After you have had a Cardiac MI

Lipitor

http://www.drugs.com/lipitor.html

Brands

  • Advicor (lovastatin with niacin) – Abbott

  • Crestor (rosuvastatin) - AstraZeneca

  • Mevacor (lovastatin) – Merck

  • Simcor (niacin / imvastatin) – Abbott

  • Altoprev (lovastatin) – Shionogi Pharma

  • Lescol (fluvastatin) – Novartis

  • Pravachol (pravastatin) -- Bristol-Myers Squibb

  • Zocor (simvastatin) – Merck

  • Caduet [atorvastatin with amlodipine (Norvasc)] – Pfizer

  • Lipitor (atorvastatin) - Pfizer

  • Vytorin (ezetimibe/simvastatin) – Merck/Schering-Plough

Baycol Fiasco

The Baycol Statin Recall and Safety Issue:

In August 2001, Bayer AG, the maker of Baycol (cerivastatin), a popular cholesterol-lowering drug used by about 700,000 Americans, pulled the medicine off the market after 31 people died from severe muscle breakdown, a well-recognized side effect of cholesterol-lowering drugs. Related articles follow:

Statins: Is the Danger in the Dose?

Here is the hard data on Baycol-associated adverse reactions. If you or someone you know is taking one of the statin cholesterol-lowering drugs, this is a "must-read" article by Jay Cohen, MD to help you understand the potential dangers that this exposes you to.

Baycol Pulled From Market as Numerous Deaths Linked to It

Baycol, a cholestrol-lowering drug (statin), has been voluntarily pulled off the market because of numerous deaths associated with its use.

The Baycol Recall: How Safe is Your Statin?

With the recall of Baycol, patients are now searching out a new drug to take its place, but are other statins really safe? Here are some precautions necessary for anyone taking Baycol or any statin.

Baycol: Another Fluoride Drug Bites the Dust

Baycol is just one of many fluoride drugs to be pulled from the market due to health hazards posed. Read about this and some of the others in this informative article written by Andreas Schuld and Wendy Small.

BMJ: Bayer faces potential fine over cholesterol lowering drug

Bayer might have to pay a fine to the German government of about $23,400 for withholding from the German authorities information on the drug's potentially fatal interaction with another drug.

Lipitor Tied to Liver, Kidney Injury, as Well as Muscle Damage

It seems that Baycol is not alone among cholesterol lowering drugs in posing serious dangers to the public. A number of legal actions are also being pursued against Pfizer Inc., the manufacturer of the Lipitor.

Excerpts from Public Citizen's Health Research Group's Petition to Require a Box Warning on All HMG-CoA Reductase Inhibitors ("Statins"):

    " ... Public Citizen, representing 135,000 consumers nationwide, hereby petitions the FDA pursuant to the Federal Food, Drug and Cosmetic Act 21, U.S.C. Section 355(e)(3), and C.F.R. 10.30, to add a black box warning and additional consistent bolded warnings about this serious problem to the label of all statins marketed in the United States."

    "Doctors and the public must be warned to immediately discontinue use of statin drugs at the onset of muscle pain, muscle tenderness, muscle weakness or tiredness."

    "Prompt cessation of the use of statins at the first sign of muscle pain, muscle tenderness, muscle weakness or tiredness and prompt evaluation by a physician including a blood test for creatine phosphokinase (a measure of muscle destruction) may avoid the progression to more extensive muscle damage, rhabdomyolysis and death."

    "Rhabdomyolysis has been reported with all statins currently marketed in the United States."

Problems with Statins - Medical Articles

Cause of Diabetes

Statins have been shown to increase your risk of diabetes through a few different mechanisms. The most important one is that they increase insulin resistance, which can be extremely harmful to your health. Increased insulin resistance contributes to chronic inflammation in your body, and inflammation is the hallmark of most diseases. In fact, increased insulin resistance can lead to heart disease, which, ironically, is the primary reason for taking a cholesterol-reducing drug in the first place! It can also promote belly fat, high blood pressure, heart attacks, chronic fatigue, thyroid disruption, and diseases like Parkinson's, Alzheimer's, and cancer.

Secondly, statins increase your diabetes risk by actually raising your blood sugar. When you eat a meal that contains starches and sugar, some of the excess sugar goes to your liver, which then stores it away as cholesterol and triglycerides. Statins work by preventing your liver from making cholesterol. As a result, your liver returns the sugar to your bloodstream, which raises your blood sugar levels.

Now, it's important to realize that drug-induced diabetes and genuine type 2 diabetes are not necessarily identical.

If you're on a statin drug and find that your blood glucose is elevated, it's possible that what you have is just hyperglycemia—a side effect, and the result of your medication. Unfortunately, many doctors will at that point mistakenly diagnose you with "type 2 diabetes," and possibly prescribe another drug, when all you may need to do is simply discontinue the statin in order for your blood glucose levels to revert back to normal. So if friends or loved ones you know are on a statin (and one in four Americans over 45 are) and they are told they have diabetes, please do them a favor and tell them about the information in this article.

Anemia

Acidosis

Sexual dysfunction

Immune depression

Cataracts

Pancreas

liver dysfunction, including a potential increase in liver enzymes

Memory loss

Muscle problems

Mercola.com> are the best known of statin drugs' adverse side effects, but cognitive problems and memory loss are also widely reported. A spectrum of other problems, ranging from blood glucose elevations to tendon problems, can also occur. There is evidence that taking statins may even increase your risk for Lou Gehrig's disease, diabetes, and even cancer. Statins currently available on the U.S. market include1 :

Don’t Give More Patients Statins

By JOHN D. ABRAMSON and RITA F. REDBERG Published: November 13, 2013 http://www.nytimes.com/2013/11/14/opinion/dont-give-more-patients-statins.html?_r=0

ON Tuesday, the American Heart Association and the American College of Cardiology issued new cholesterol guidelines that essentially declared, in one fell swoop, that millions of healthy Americans should immediately start taking pills — namely statins — for undefined health “benefits.”

This announcement is not a result of a sudden epidemic of heart disease, nor is it based on new data showing the benefits of lower cholesterol. Instead, it is a consequence of simply expanding the definition of who should take the drugs — a decision that will benefit the pharmaceutical industry more than anyone else.

The new guidelines, among other things, now recommend statins for people with a lower risk of heart disease (a 7.5 percent risk over the next 10 years, compared with the previous guidelines’ 10 to 20 percent risk), and for people with a risk of stroke. In addition, they eliminate the earlier criteria that a patient’s “bad cholesterol,” or LDL, be at or above a certain level. Although statins are no longer recommended for the small group of patients who were on the drugs only to lower their bad cholesterol, eliminating the LDL criteria will mean a vast increase in prescriptions over all. According to our calculations, it will increase the number of healthy people for whom statins are recommended by nearly 70 percent.

This may sound like good news for patients, and it would be — if statins actually offered meaningful protection from our No. 1 killer, heart disease; if they helped people live longer or better; and if they had minimal adverse side effects. However, none of these are the case.

Statins are effective for people with known heart disease. But for people who have less than a 20 percent risk of getting heart disease in the next 10 years, statins not only fail to reduce the risk of death, but also fail even to reduce the risk of serious illness — as shown in a recent BMJ article co-written by one of us. That article shows that, based on the same data the new guidelines rely on, 140 people in this risk group would need to be treated with statins in order to prevent a single heart attack or stroke, without any overall reduction in death or serious illness.

At the same time, 18 percent or more of this group would experience side effects, including muscle pain or weakness, decreased cognitive function, increased risk of diabetes (especially for women), cataracts or sexual dysfunction.

Perhaps more dangerous, statins provide false reassurances that may discourage patients from taking the steps that actually reduce cardiovascular disease. According to the World Health Organization, 80 percent of cardiovascular disease is caused by smoking, lack of exercise, an unhealthy diet, and other lifestyle factors. Statins give the illusion of protection to many people, who would be much better served, for example, by simply walking an extra 10 minutes per day.

Aside from these concerns, we have more reasons to be wary about the data behind this expansion of drug therapy.

When the last guidelines were issued by the National Heart, Lung, and Blood Institute in 2001, they nearly tripled the number of Americans for whom cholesterol-lowering drug therapy was recommended — from 13 million to 36 million. These guidelines were reportedly based strictly on results from clinical trials. But this was contradicted by the data described in the document itself.

For example, even though the guidelines recommended that women between the ages of 45 and 75 at increased risk of heart disease and with relatively high LDL levels take statins, the fine print in the 284-page document admitted, “Clinical trials of LDL lowering generally are lacking for this risk category.” The general lack of evidence for LDL level targets is why they have been dropped from the current guidelines. In fact, committee members noted that cholesterol lowered by drugs may not have the same effect as cholesterol lowered by nondrug methods, such as diet, exercise and being lucky enough to have good genes.

The process by which these latest guidelines were developed gives rise to further skepticism. The group that wrote the recommendations was not sufficiently free of conflicts of interest; several of the experts on the panel have recent or current financial ties to drug makers. In addition, both the American Heart Association and the American College of Cardiology, while nonprofit entities, are heavily supported by drug companies.

The American people deserve to have important medical guidelines developed by doctors and scientists on whom they can confidently rely to make judgments free from influence, conscious or unconscious, by the industries that stand to gain or lose.

We believe that the new guidelines are not adequately supported by objective data, and that statins should not be recommended for this vastly expanded class of healthy Americans. Instead of converting millions of people into statin customers, we should be focusing on the real factors that undeniably reduce the risk of heart disease: healthy diets, exercise and avoiding smoking. Patients should be skeptical about the guidelines, and have a meaningful dialogue with their doctors about statins, including what the evidence does and does not show, before deciding what is best for them.

John D. Abramson, a lecturer at Harvard Medical School and the author of “Overdosed America: The Broken Promise of American Medicine,” serves as an expert in litigation involving the pharmaceutical industry. Rita F. Redberg is a cardiologist at the University of California, San Francisco Medical Center and the editor of JAMA Internal Medicine.

Problems Overview

Dr. JAN NEWMAN| Physician 3 days ago 2014-07-30 Thank you for bringing up this essential topic. We forget that we are treating 199 patients with statins to help one patient not have a heart attack. Not have longer life expectancy; to not have a heart attack. For those who would like to put statins in the water supply, this needs to be in BOLD print. Statins are not innocuous. Repeated studies have shown the complication rate to be under reported.

Medical Studies

Please AHA, never use Relative Risk and p-value as the base for guideline change. A significant Relative risk is adequate when recommend lifestyle change but adding pills like statins with all the adverse events? Definitely NO! I would be leery about other drugs for primary prevention especially those names with including PCSK----mab or ---cept. These drugs will affect other unrelated molecules in the TCA cycle or other biological reaction vital to our bodily function.

“Pills Do Not Confer Heart Health” is such a good statement. We should stay with lifestyle change in primary prevention. Because the event rate is low in primary prevention, any intervention with pills would yield minimal benefit with large risk to large % of people who will not have events anyway. For those who support for statin in primary prevention, I will say again what I said it many times before (in heartwire. org) and a new study actually had proven that. (Pencina, M et al. NEJM 2014)

Pencina MJ, Navar-Boggan AM, D'Agostino RB, Sr., Williams K, Neely B, Sniderman AD, et al. (2014). Application of new cholesterol guidelines to a population-based sample. N Engl J Med 370(15):1422-31.

Statins had demostrated in a lot of medical trials benefits in primary and secondary CV prevention. I think Statins are the more saftiest and efficacious drugs in CV prevention. So, I can't understand the doubt expressed in your lesson 3. Of course my position is the opposite, and I'm going to prescribe statins in primary and secondary Cardiovascular prevention as I do it today. Dr. Pedro Lipszyc - Chairman Pharmacology Depàrtmen. University of Buenos Aires Medical School

Countries where lipid levels are usually low have little in the way of ATD events .... http://wholehealthsource.blogspot.it/2008/08/cardiovascular-risk-factors-on-kitava_14.html

To judge statins from what it can achieve for mortality in a 4-5 year perpective is not the relevant issue. What about stroke? The recent data on stroke incidence the last 20 years in the USA gives an important reminder of perhaps the most important protective effect of statins: The prevention of a devastating stroke. Look at the data from WOSCOPS, ASCOT and JUPITER, and one can easily see that important benefits do not translate into mortality effects unless you follow patients in a lot more than the standard 4-5 years of a clinical study.

10yr Prosper Sep'13

The only statin study to go more than 10 years (PROSPER sept 2013) showed greater mortality in the active group than the placebo group! True, there were fewer cardiac deaths, but side effects killed more people! What ever happened to "first do no harm"? Take a statin if you want less risk (not no risk) of dying from a heart attack but are happy to die sooner with weak muscles and alzheimer's like dementia.

References

  • Statin Expansion: Hold the Rx Rita F. Redberg, OpEd, MDDisclosures March 26, 2014 http://www.medscape.com/viewarticle/822462

Abramson JD, Redberg RF. Don't give more patients statins. New York Times. November 13, 2013. http://www.nytimes.com/2013/11/14/opinion/dont-give-more-patients-statins.html?_r=0 Accessed March 6, 2014.

Ridker PM, Cook NR. Refining the American guidelines for prevention of cardiovascular disease -- authors' reply. Lancet. 2014;383:600.

Estruch R, Ros E, Salas-Salvadó J, et al; PREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368:1279-1290. Abstract

Ray KK, Seshasai SR, Erqou S, et al. Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants. Arch Intern Med. 2010;1700:1024-1031.

Carter AA, Gomes T, Camacho X, Juurlink DN, Shah BR, Mamdani MM. Risk of incident diabetes among patients treated with statins: population based study. BMJ. 2013;346:f2610.

Wilson D. Health guideline panels struggle with conflicts of interest. New York Times. November 2, 2011. http://www.nytimes.com/2011/11/03/health/policy/health-guideline-panels-struggle-with-conflicts-of-interest.html Accessed March 17, 2014.

Statins Harden Arteries?

I have read articles (from Europe) that shows statins cause more health problems than we want to admit. Studies have shown that statins while it lowers lipid profiles ( the " bad ones") it causes hardening of the arteries. However, we have sanctified our continued use by promoting " the benefits out ways the risk." While I worked on the CT surgery team at a local hospital, 99.99 percent of patient with a coronary event was on a statin. Forty to fifty percent took the statin because the media said it was good for them. When asked if they had high cholesterol levels, they said they did not know. They simply took it because it was promoted by the media. Doctors somehow felt obligated to put patients on statins otherwise face penalty from insurance companies. While I do agree that there are benefits to using statins and other lipid lowering medications, the patient selection should be individualized and not make it an across the board phenomenon. Let's encourage our patient to move more, play more, socialize more, drink more water, and among others choose our meals in a more balance manner.

Problems with Muscles

Problems with the Brain

DA issued a warning on memory loss with Statin use making it a true "no brainer" to use it. I think we should have some understanding with some of the medical doctors who are still adherant believers in Statin therapy Rx for MI regardless of the good studies that show otherwise.

Yes, statins have been a waste of money for the public, but a big bonus to pharma,..a scheme based on a decades-old non-scientific speculative consensus that "cholesterol" is bad bad bad, even though it's required for us to have a brain. Too bad our brains aren't automatically smart.

Several patients have reported developmentt of severe myopathy followed by diagnosis of ALS following Statin therapy. I don't have any statistics on it. But wonder if other physicians have noted similar correlation of this very serious side effect.

Statins vs Niacin

INDICATION FOR NIACIN IN STATIN INTOLLERANT PATIENTS (AS ALREADY RECALLED BY SOME COLLEGUES IN COMMENTS). THE STUDIES THAT YOU MENTIONED DEMONSTRATED ONLY THAT NIACIN ON TOP OF STATIN IS NOT BENEFICIAL, NOT THAT NIACIN IS NOT BENEFICIAL.

Some Statins Can cause Cancer in Rats

In the January 2, 1996 issue of the Journal of the American Medical Association, an article showed that the cholesterol lowering drug, lovostatin (brand name Mevacor) causes cancer in rats. An article in the March issue of Clinical Cancer Research shows that lovostatin can help to cure cancer. Whom do you believe?

Cancer patients were given high doses of lovostatin and their tumors became smaller. The dose was 75 times that given to people who are trying to lower their cholesterols and it caused significant muscle pain. Lovostatin lowers cholesterol by reducing the amount of cholesterol manufactured by the liver. It also lowers blood levels of ubiquinone which causes the muscle pain. When the cancer patients were given ubiquinone supplements, their muscle pain disappeared. Several other studies show that lovostatin in high doses may help to prevent and treat certain types of cancers.

How then would you explain why a drug that is actively being studied to treat cancer, has been shown to cause it? In the article in the Journal of the American Medical Association, rats were given doses of lovostatin that were 300 times the dose recommended for humans. At up to 60 times the recommended dose, there was no increase in tumor rate. This shows that the dose of a drug determines its effects. At one dose, a drug may cause cancer, while at another dose, it may help to treat it. We already have another treatment that prevents heart attacks as well as certain types of cancer. It's a low-fat, high fruit, vegetable, whole grain and bean diet.

By Gabe Mirkin, M.D., for CBS Radio News

1) JAMA January 2, 1996.

2) A Thibault, D Samid, AC Tompkins, WD Figg, MR Cooper, RJ Hohl, J Trepel, B Liang, N Patronas, DJ Venzon, E Reed, CE Myers. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clinical Cancer Research 2: 3 (MAR 1996):483-491. Lovastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (the major regulatory enzyme of the mevalonate pathway of cholesterol synthesis), displays antitumor activity in experimental models. Cyclical treatment with lovastatin markedly inhibited the mevalonate pathway, evidenced by reductions in both cholesterol acid ubiquinone concentrations, by up to 43 and 49% of pretreatment values, respectively. Treatment with ubiquinone was associated with reversal of lovastatin-induced myopathy, and its prophylactic administration prevented the development of this toxicity. Lovastatin given p.o. at a dose of 25 mg/kg daily for 7 consecutive days is well tolerated.

Statins in Depth

Lovostatin

Statins Should NEVER Be Used By Pregnant Women

One in four Americans over the age of 45 is now taking these drugs, and few are properly warned about the related health risks. Part of the problem is that many doctors are not even aware of all the risks. A study published last spring highlighted this dilemma.

Most disturbingly, the researchers found that physicians were lacking in awareness of the teratogenic risks3 (ability to cause fetal malformations) of statins and other cardiovascular drugs they prescribed for their pregnant patients. The study followed an earlier report, which had concluded statins should be avoided in early pregnancy due to their teratogenic capability4. An even earlier 2003 study5 had already established that cholesterol plays an essential role in embryonic development, and that statins could play a part in embryonic mutations or even death...

Indeed, it's difficult to look at these facts and not reach the conclusion that the pharmaceutical industry is quite willing to sacrifice human lives for profit. Statins are in fact classified as a "pregnancy Category X medication." Meaning, it causes serious birth defects, and should NEVER be used by a woman who is pregnant or planning a pregnancy.

Parents Beware: Outrageous Push to Put Kids on Statin Drugs!

In a bold attempt to increase profits before the patent runs out, Pfizer has introduced a chewable kid-friendly version of Lipitor. Its US patent for Lipitor expired in November 2011, and seeking to boost sales of the drug, children have become the new target market, and the conventional medical establishment is more than happy to oblige.

Researchers and many doctors are now calling for universal school screening of children to check for high cholesterol to find those "in need of treatment." In addition, older siblings, parents, and other family members might be prompted to get screened as well, the researchers say, which would uncover additional, previously undiagnosed adults in need of the drug.

This is clearly NOT the way to improve public health. On the contrary, it could produce a new, massive wave of extremely dire health consequences in just a few years' time.

So rather than improving school lunches, which would cost about a dollar a day per child, they'd rather "invest" ten times that for tests and drugs that in no way, shape, or form address the root cause, which is an improper, unhealthy diet! All they're doing is allowing all the industries to maintain or increase their profits: Big Pharma, Big Sugar, Big Corn and the processed food industry.

Who pays?

You and your children! And in far more ways than one!

Ninety-Nine Out of 100 People Do Not Need Statin Drugs - Mercola.com

Tens of millions of Americans are taking cholesterol-lowering drugs—mostly statins—and some "experts" claim that many millions more should be taking them. I couldn't disagree more.

That these drugs have proliferated the market the way they have is a testimony to the power of marketing, corruption and corporate greed, because the odds are very high— greater than 100 to 1—that if you're taking a statin, you don't really need it. The ONLY subgroup that might benefit are those born with a genetic defect called familial hypercholesterolemia, as this makes them resistant to traditional measures of normalizing cholesterol.

And, even more importantly, cholesterol is NOT the cause of heart disease.

If your physician is urging you to check your total cholesterol, then you should know that this test will tell you virtually nothing about your risk of heart disease, unless it is 330 or higher. HDL percentage is a far more potent indicator for heart disease risk. Here are the two ratios you should pay attention to:

    HDL/Total Cholesterol Ratio: Should ideally be above 24 percent. If below 10 percent, you have a significantly elevated risk for heart disease.
    Triglyceride/HDL Ratio: Should be below 2.

I have seen a number of people with total cholesterol levels over 250 who were actually at low risk for heart disease due to their elevated HDL levels. Conversely, I have seen many people with cholesterol levels under 200 who had a very high risk of heart disease, based on their low HDL. Your body NEEDS cholesterol—it is important in the production of cell membranes, hormones, vitamin D, and bile acids that help you to digest fat. Cholesterol also helps your brain form memories and is vital to your neurological function. There is also strong evidence that having too little cholesterol INCREASES your risk for cancer, memory loss, Parkinson's disease, hormonal imbalances, stroke, depression, suicide, and violent behavior.

Major Medical Studies

Jupiter Trial 2008

Major Statin Drug Study Found to Be Flawed

A study known as the JUPITER trial initially suggested cholesterol-lowering statin drugs might prevent heart-related death in many more people than just those with high cholesterol. But two years after its publication in 2008, researchers came out saying the JUPITER results are flawed -- and that they do not support the benefits initially reported. Not only is there no "striking decrease in coronary heart disease complications," but a more recent report has also called into question drug companies' involvement in such trials.

According to a report by ABC News2 :

    "... major discrepancies exists between the significant reductions in nonfatal stroke and heart attacks reported in the JUPITER trial and what has been found in other research ... 'The JUPITER data set appears biased,' [the researchers] wrote in conclusion."

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